Composition: Ampicillin sodium and cloxacillin sodium are available as : Sterile powder for preparing the equivalent of 500mg ampicillin and 500mg cloxacillin per vial. Pharmacological Action: Penicillins Indications The use of this antibiotic may lead to the appearance of resistant strains of organisms and sensitivity testing should be carried out wherever possible to ensure the appropriateness of the therapy. Infections are caused by susceptible organisms where a mixed inflection is present and includes penicillin-resistant staphylococci. Contra-indications Known allergy to penicillin or cephalosporins, Cases of cross-sensitivity have been reported. Babies born of hypersensitive mothers in the neonatal period. The oral dosage forms are not recommended for chronic severe or deep-seated infections such as subacute bacterial endocarditis, meningitis or syphilis. Ampiclox should not be administered by sub-conjunctival injection or used as an eye drop as it contains cloxacillin. Warnings When administered to a patient with penicillin allergy anaphylactic shock may occur. corticosteroids and antihistamines should be used to treat anaphylaxis. Use with caution in patients with a known history of allergy. Because of the variability in intestinal absorption of cloxacillin-containing products oral administration is not a suitable substitute for the parenteral route in the treatment of severe infections. Storage instructions Containers should be kept tightly closed in a cool (below 25C) dry place. Once prepared, AMPICLOX must be used immediately, KEEP OUT OF REACH OF CHILDREN.