| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | Injection |
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Indications
The indications include cardiac, pulmonary, hepatic and renal oedema.
Dosage and Administration
Usage: Furosemide Injection 20mg/2ml are for intramuscular or for intravenous administration and must always be given slowly.
Adults: Initially, the control rate should not exceed 4 mg/minute
Elderly: Elimination of furosemide is generally slower in the elderly. Dosage should be titrated until the required effect is achieved.
Paediatric population: Dosages for children range from 0.5 - 1.5mg/kg weight daily up to a maximum total daily dose of 20mg.
Precautions & Warning:
1. Conditions requiring correction before furosemide is started : Hypotension ; Hypovolaemia ; Severe electrolyte disturbances : particularly hypokalaemia, hyponatraemia and acid-base disturbances ; Furosemide is not recommended in patients at high risk for radiocontrast nephropathy, it should not be used for diuresis as part of the preventative measures against radiocontrast-induced nephropathy.
2. Particular caution and/or dose reduction required:difficulty with micturition including prostatic hypertrophy; diabetes mellitus ; gout ; patients with hepatorenal syndrome ; impaired hepatic function;impaired renal function ; adrenal disease ; hypoproteinaemia e.g. nephritic syndrome ; acute hypercalcaemia ; Treatment of hypercalcaemia with a high dose of furosemide results in fluid and electrolyte depletion - meticulous fluid replacement and correction of electrolyte required ; Patients who are at risk from a pronounced fall in blood pressure ; premature infants
3. Avoidance with other medicines
Concurrent NSAIDs should be avoided, if not possible diuretic effect of furosemide may be attenuated ACE-inhibitors & Angiotensin II receptor antagonists, severe hypotension may occur , dose of furosemide should be reduced/stopped (3 days) before starting or increasing the dose of these.
Contraindications:
1. Hypersensitivity to the active substance or to any of the excipients
2. Hypersensitivity to amiloride, sulphonamides or sulphonamide derivatives
3. Hypovolaemia and dehydration (with or without accompanying hypotension)
4. Severe hypokalaemia: severe hyponatraemia .
5. Comatose or pre-comatose states associated with hepatic cirrhosis.
6. Anuria or renal failure with anuria not responding to furosemide, renal failure as a result of poisoning by nephrotoxic or hepatotoxic agents, renal failure associated with hepatic coma
7. Addison's disease .
8. Porphyria
9. Breast-feeding women.
Adverse Reactions:
1.Blood and lymphatic system disorders : Thrombocytopenia
2. Eye disorders : Visual disturbance
3.Ear and labyrinth disorders: Ear and labyrinth disorders.
4.Vascular Disorder
5.Skin and subcutaneous tissue disorders
6.General disorders and administration site conditions : Fatigue
7.Gastrointestinal disorders
Storage instructions:
Do not store above 25° C
Do not refrigerate or freeze.
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