COMPOSITION: Each sugar -coated tablet contains: lbuprofen BP 400 mg
INDICATIONS: lbuprofen provides relief from mild to moderate pain in conditions such as dysmenorrhoea, migraine, post operative pain, rheumatic disorders such as ankylosing spondylitis, osteoarthritis and rheumatoid arthritis including juvenile , rheumatoid arthritis and in other musculo-skeletal and joint disorders such as sprains and strains.
CONTRAINDICATIONS: Ibuprofen is contraindicated in the following conditions: 1. Bronchospasm 2. Known sensitivity to aspirin 3. Peptic ulcer 4. Recent gastrointestinal bleeding 5. Renal failure 6. Hypertension on treatment
PHARMACOLOGICAL ACTIONS: The propionic acid derivatives are all effective inhibitors of cyclo-oxygenase responsible for the biosynthesis of prostaglandins. All of these agents alter platelet function and prolong bleeding time. Ibuprofen is well absorbed after oral administration. Ibuprofen is rapidly metabolized and eliminated in the urine. The excretion of lbuprofen is virtually complete with in24 hours after the last dose. The serum half life is 1.8 to2.0 hours.
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