| Application: | Internal Medicine |
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| Usage Mode: | for Injection |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Shape: | Powder |
| Type: | Generic Medicines |
| Samples: |
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| Customization: |
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Indications:
Benzylpenicillin benzathine is indicated in adults, adolescents, children and neonates for the treatment and prophylaxis of the following infections:
For the treatment of:
- erysipelas
- syphilis: early syphilis (primary and secondary)
- latent syphilis (except for neurosyphilis and presence of pathological CSF findings)
- yaws
- pinta
For the prophylaxis of:
- rheumatic fever (chorea, rheumatic carditis)
- poststreptococcal glomerulonephritis
- erysipelas
Dosage and Administration:
Posology
The dosing recommendations depend on the severity and the type of infection, the age and the hepato-renal function of patients.
Method of administration
The preparation is strictly for intramuscular injection.
The injection must not be administered into tissue with reduced perfusion.
Contra-indications:
- Hypersensitivity to penicillins or any of the excipients.
- History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. cephalosporin, carbapenem or monobactam).
- When lidocaine solution is used as a solvent, contraindications to lidocaine must be excluded before intramuscular injection of benzylpenicillin benzathine.
Drug interactions:
Concomitant administration of benzylpenicillin benzathine is not recommended with:
- bacteriostatic antibiotics: based on the general principle not to combine bactericidal and bacteriostatic antibiotics.
Caution should be exercised when co-administering the following:
- probenecid
- methotrexate
- anticoagulants
Storage instructions:
Do not store above 25°C.
Following reconstitution, benzylpenicillin benzathine should be used immediately.
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