Ampicilllin+Sulbactam for Injection 1.5g, GMP Medicine

• Application: Internal Medicine
• Usage Mode: For external use
• Suitable for: Elderly, Adult
• State: Powder
• Shape: Powder
• Pack: 1g/10ml, 10′s/Box
• Model NO.: AMC13021
• Cap: Al or Al with Plastic
• Transport Package: 10′s / Box, 100boxes/ CTN
• Specification: 1.5g/10ml
• Trademark: MEDIPHARM/OEM
• Origin: China
• HS Code: 3004909099
• Production Capacity: 10000ctns Per Month

Product Description

Ampicilllin+Sulbactam For Injection
 

Characters

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This product is white or quasi-white powder.

Indications:
This product is suitable for the treatment of infections caused by sensitive bacteria. Typical indications include: sinusitis, otitis media, epiglottitis, bacterial pneumonia and other upper and lower respiratory tract infections; Urinary tract infection, pyelonephritis; Peritonitis, cholecystitis, endometritis, pelvic cellulitis and other intraperitoneal infections; Bacterial bacteremia; Skin, soft tissue, bone and joint infection; Gonorrhea infection.

Usage and Dosage:

Sulbactam sodium for injection ampicillin sodium can be intramuscular or intravenous injection. Can be diluted with the following solution:
Total dose (g) Equivalent dose of sulbactam/ampicillin (g) Volume of packaged diluent (ml) Final diluted concentration (mg/ml)
0.8 125-250 per vial of 10 ml
1.6 125-250 per vial of 10 ml
1.5 0.5-1.0 20 ml vials 3.2 125-250
3.0 1.0-2.0 20ml vials 6.4 125-250
0.75 0.25-0.5 100ml Packing unit 25 10-20
1.5 0.5-1.0 100ml packing unit 50 10-20
3.0 1.0-2.0 100ml Packing unit 100 10-20
Sulbactam sodium and ampicillin sodium for injection should be prepared using sterile water for injection or other compatible solutions for intravenous injection. To be sure of complete dissolution, wait until the powder is invisible to the naked eye after the foam disappears. This dose can be administered intravenously for a duration of more than 3 minutes or to increase the volume of diluent by intravenous infusion for a duration of more than 15-30 minutes.
Sulbactam sodium ampicillin sodium can be used for deep intramuscular injection. If pain occurs at the injection site, the powder can be prepared with 0.5% anhydrous lidocaine hydrochloride sterilizing water for injection.
Adult usage
Sulbactam sodium for injection The usual daily dose of ampicillin sodium is 1.5-12 grams, divided every 6 or 8 hours. The maximum daily dose of sulbactam is 4 grams. It can be injected every 12 hours to treat mild and moderate infections.
Severity of infection Sulbactam sodium for injection Daily dose of ampicillin sodium (g)
Mild 1.5-3 (0.5+1 to 1+2)
Moderate maximum dose 6 (2+4)
Severe maximum dose 12 (4+8)
The frequency of administration may be increased or decreased according to the severity of the patient's infection and renal function. Treatment usually continues until 48 hours after the fever has subsided or other abnormal signs return to normal. Ampicillin should generally be treated for 5-14 days, but in severe cases the course of treatment may be extended or ampicillin may be added.
When treating infections in patients with sodium restriction, a 1500 mg dose of sulbactam sodium for injection containing approximately 115 mg (5 ml) of ampicillin sodium should be noted.
For the prevention of surgical infection, 1.5-3 grams of sulbactam sodium and ampicillin sodium for injection should be given during the induction period of anesthesia to allow sufficient time for effective serum and tissue concentrations to be achieved during surgery. This dose can be repeated every 6-8 hours; It is usually discontinued 24 hours after a major surgical procedure, except when sulbactam sodium for injection and ampicillin sodium are used for treatment.
For the treatment of uncomplicated gonorrhea, a single dose of 1.5 grams of sulbactam sodium ampicillin sodium for injection can be injected. Prolongation of sulbactam and ampicillin plasma concentrations should be combined with prolongation of prolongation of prolongation of sulbactam and ampicillin plasma concentrations.
Medication for patients with impaired renal function
In patients with severely impaired renal function (creatinine clearance <30 mL/min), the pharmacokinetic parameters of sulbactam and ampicillin were similarly affected, so the plasma concentration ratios remained constant. Sulbactam sodium/ampicillin should be administered less frequently in these patients, as is usual with ampicillin.

Drug Interactions:
Allopurinol: Significantly higher rates of skin rash have been reported in patients treated with ampicillin and allopurinol compared with those treated with ampicillin alone.
Aminoglycoside antibiotics: in vitro test results showed that ampicillin and aminoglycoside antibiotics mixed, can mutually inactivate the action of both; If these two antibacterial drugs are needed together, they should be injected into different parts of the patient at least one hour apart.
Anticoagulants: Penicillin antibiotics administered externally from the gastrointestinal tract may alter the results of platelet aggregation and agglutination tests. Anticoagulants can be added to counteract this effect.
Bacteriostat (erythromycin, sulfonamides and tetracycline) : The bactericidal action of penicillin antibiotics may affect bacteriostat. It is best to avoid their co-use.
Estrogen-containing oral contraceptives: Cases have been reported of women using oral contraceptives with ampicillin having reduced contraceptive effectiveness, resulting in unplanned pregnancies. Although this is highly unlikely, patients on ampicillin should be given the option of using an alternative contraceptive or an enhanced one.
Methotrexate: Combination with penicillin antibiotics reduces the clearance of methotrexate, thus increasing the toxicity of methotrexate. The patient should be closely monitored. It may be necessary to increase the dose of leucovorin and extend the interval between dosing.
Bensulfamodes: when bensulfamodes is combined with this product, the former can reduce the secretion of ampicillin and sulbactam in the renal tubules, resulting in the increase and prolongation of the serum peak concentration of the latter, and at the same time eliminate the prolongation of the half-decline period and increase the risk of poisoning.
Drug interactions in laboratory tests:
False positive results were observed in urine glucose analysis using the Benedict, Fehling, and ClinitestTM reagents. A transient decrease in plasma total conjugated estriol, glucosidate-estriol, conjugated.This phenomenon can also occur in patients treated with sulbactam sodium and ampicillin sodium for injection.
Storage:
Airtight, stored below 30ºC.