| Customization: | Available |
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| Application: | Internal Medicine |
| Usage Mode: | For oral administration |
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Use:
Diosmin has been widely used since 1969 as a phlebotonic and vascular protector for venous leg ulcers and hemorrhoids; however, clinical data to support these uses are limited. Most, but not all available clinical data support its use for chronic venous insufficiency (CVI) and hemorrhoid disease, both acute and chronic. Diosmin has also been used to improve postoperative cardiac function and outcomes in adults undergoing coronary artery bypass grafting (CABG) surgery, for pelvic congestion caused by pelvic varicose veins in men and women, and for varicoceles in men; however, few large-scale quality clinical trials support these uses.
Pregnancy/Lactation:
Avoid use. Diosmin is not recommended for use in pregnant or breast-feeding women.
Interactions:
Serum concentrations may be increased by coadministration of drugs metabolized by cytochrome P450 (CYP-450) 2E1 or 2C9, or by P-glycoprotein.
Adverse Reactions:
The most common adverse effects are mild GI and autonomic disturbances (pruritus, erythema, dermatitis [hives, itching], stomach and epigastric pain, nausea, diarrhea, and dizziness); cardiac arrhythmias (tachycardia) and hemolytic anemia have also been documented. Rare excessive peripheral vasoconstriction and ischemic damage have been reported.
Toxicology:
Extensive safety evaluations conducted with MPFF found no risk of toxicity
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