| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | For oral administration |
|
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Indicatios:
Cefuroxime axetil is indicated for the treatment of the infections listed below in adults and children from the age of 3 months.
- Acute streptococcal tonsillitis and pharyngitis.
- Acute bacterial sinusitis.
- Acute otitis media.
- Acute exacerbations of chronic bronchitis.
- Cystitis
- Pyelonephritis.
- Uncomplicated skin and soft tissue infections.
- Treatment of early Lyme disease.
Dosage and administration:
Posology
The usual course of therapy is seven days (may range from five to ten days).
Table 1. Adults and children (≥40 kg)
|
Indication |
Dosage |
|
Acute tonsillitis and pharyngitis, acute bacterial sinusitis |
250 mg twice daily |
|
Acute otitis media |
500 mg twice daily |
|
Acute exacerbations of chronic bronchitis |
500 mg twice daily |
|
Cystitis |
250 mg twice daily |
|
Pyelonephritis |
250 mg twice daily |
|
Uncomplicated skin and soft tissue infections |
250 mg twice daily |
|
Lyme disease |
500 mg twice daily for 14 days (range of 10 to 21 days) |
Table 2. Children (<40 kg)
|
Indication |
Dosage |
|
Acute tonsillitis and pharyngitis, acute bacterial sinusitis |
10 mg/kg twice daily to a maximum of 125 mg twice daily |
|
Children aged two years or older with otitis media or, where appropriate, with more severe infections |
15 mg/kg twice daily to a maximum of 250 mg twice daily |
|
Cystitis |
15 mg/kg twice daily to a maximum of 250 mg twice daily |
|
Pyelonephritis |
15 mg/kg twice daily to a maximum of 250 mg twice daily for 10 to 14 days |
|
Uncomplicated skin and soft tissue infections |
15 mg/kg twice daily to a maximum of 250 mg twice daily |
|
Lyme disease |
15 mg/kg twice daily to a maximum of 250 mg twice daily for 14 days (10 to 21 days) |
There is no experience of using Cefuroxime axetil in children under the age of 3 months.
Drug interactions:
Drugs which reduce gastric acidity may result in a lower bioavailability of cefuroxime axetil compared with that of the fasting state and tend to cancel the effect of enhanced absorption after food.
Cefuroxime is excreted by glomerular filtration and tubular secretion. Concomitant use of probenecid is not recommended. Concurrent administration of probenecid significantly increases the peak concentration, area under the serum concentration time curve and elimination half-life of cefuroxime.
Concomitant use with oral anticoagulants may give rise to increased INR.
Storage:
Store in the original packaging in order to protect from moisture
This medicinal product does not require any special temperature storage conditions
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