Indications:
1. Treat nontoxic goiter (normal thyroid function).
2. Prevent recurrence of goiter after thyroidectomy.
3. Alternative treatment of hypothyroidism.
4. Adjuvant treatment of hyperthyroidism with antithyroid drugs.
5. Postoperative inhibitory treatment of thyroid cancer.
6. Thyroid inhibition test.
Usage And Dosage:
should be based on the results of laboratory and clinical tests.
Since T4 and fT4 levels are elevated in many patients, the basal concentration of TSH in the serum is a reliable basis for determining treatment.
In addition to the importance of rapid dose increase in neonates, thyroid hormone therapy should generally start at low dose and gradually increase every 2 to 4 weeks until full dose is reached.
In elderly patients, patients with coronary heart disease, and patients with severe or long-term hypothyroidism, the initiation of thyroid hormone therapy should be particularly noted, with a low initial dose (e.g. 12.5μg/ day) and a slow increase over a longer period of time (e.g. 12.5μg/ day every two weeks). It is also important to note that TSH levels cannot be completely corrected if the final maintenance dose given to a patient is below the optimal dose.
Experience has shown that low doses are effective in patients with low body weight and large nodular goiter.
Daily dose of levothyroxine sodium tablets
Dosage 50μg dosage 100μg dosage
Goiter (normal thyroid function) 75-200μg 3/4- 4 tablets 3/4-2 tablets once daily
Prevention of thyroid recurrence after thyroidectomy 75-200μg 3/4- 4 tablets 3/4-2 tablets once daily
Hypothyroidism in adults
- Initial dose 25-50μg 1/2-1 tablet 1/4-1/2 tablet once daily
(Increase 25-50μg every 2-4 weeks after initial dose until maintenance dose)
- Maintenance dose 100-200μg 2-4 tablets 1-2 tablets once daily
Hypothyroidism in children
- Initial dose 12.5-50μg 1/4-1 tablet 1/8-1/2 tablet once daily
- Maintenance dose 100-150μg/m2 body surface area 2-3 tablets /m2 body surface area 1-2/3 tablets /m2 body surface area once daily
Adjunct therapy for hyperthyroidism 50-100μg 1-2 tablets 1/2 tablets once daily
Postoperative thyroid cancer 150-300μg - 1 1/2 -3 tablets once daily
Thyroid suppression test 200μ g-2 tablets once daily
50μg can be used in combination with other high-dose tablets in order to accurately adjust the dose of the left thyroid cancer suppressive therapy (recommended daily dose 150-300μg).
Levothyroxine sodium tablets should be taken half an hour before breakfast on an empty stomach with a daily dose of appropriate liquid (e.g., half a glass of water).
Infants should take the full dose at least 30 minutes before their first meal each day. The tablets can be mashed into a suspension with just the right amount of water. But keep in mind that this step should be done temporarily before taking the medicine. The resulting drug suspension can then be administered in an appropriate liquid.
In general, lifetime medication should be taken in patients with hypothyroidism, after partial or total thyroidectomy, and to prevent recurrence of the goiter after removal. When combined for hyperthyroidism, the duration of administration should be the same as that of antithyroid drugs.
For benign goiter, 6 months to 2 years of treatment is necessary. To avoid recurrence of goitre, low doses of iodine (100-200 μg) are recommended for prophylaxis after the goitre has shrunk. Surgery and radioactive iodine should be considered if these medications are insufficient to relieve the goitre.
Storage:
Store under 25ºC in dry environment, away from light.
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