| Application: | Internal Medicine |
|---|---|
| Usage Mode: | Injection |
| Suitable for: | Elderly, Children, Adult |
| State: | Liquid |
| Shape: | Injection |
| Type: | Organic Chemicals |
| Samples: |
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| Customization: |
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Audited Supplier Indications:
Omeprazole for intravenous use is indicated as an alternative to oral therapy for the following indications i.e.
• Treatment of duodenal ulcers
• Prevention of relapse of duodenal ulcers
• Treatment of gastric ulcers
• Prevention of relapse of gastric ulcers
• In combination with appropriate antibiotics, Helicobacter pylori (H. pylori) eradication in peptic ulcer disease
• Treatment of NSAID-associated gastric and duodenal ulcers
• Prevention of NSAID-associated gastric and duodenal ulcers in patients at risk
• Treatment of reflux oesophagitis
• Long-term management of patients with healed reflux oesophagitis
• Treatment of symptomatic gastro-oesophageal reflux disease
• Treatment of Zollinger-Ellison syndrome
Dosage and Administration:
In patients where the use of oral medicinal products is inappropriate, Omeprazole IV 40 mg once daily is recommended. In patients with Zollinger-Ellison Syndrome the recommended initial dose of Omeprazole given intravenously is 60 mg daily. Higher daily doses may be required and the dose should be adjusted individually. When doses exceed 60 mg daily, the dose should be divided and given twice daily.
Omeprazole is to be administered in an intravenous infusion for 20-30 minutes.
Precautions & Warning:
In the presence of any alarm symptoms (e.g. significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melena) and when gastric ulcer is suspected or present, malignancy should be excluded, as treatment may alleviate symptoms and delay diagnosis.
Omeprazole, as all acid-blocking medicinal products, may reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. This should be considered in patients with reduced body stores or risk factors for reduced vitamin B12 absorption on long-term therapy.
Omeprazole is a CYP2C19 inhibitor. When starting or ending treatment with omeprazole, the potential for interactions with medicinal products metabolised through CYP2C19 should be considered.
Treatment with proton pump inhibitors may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter.
For patients expected to be on prolonged treatment or who take proton pump inhibitors with digoxin or medicinal products that may cause hypomagnesaemia (e.g., diuretics), health care professionals should consider measuring magnesium levels before starting proton pump inhibitor treatment and periodically during treatment.
Contra-indications:
Hypersensitivity to omeprazole, substituted benzimidazoles or to any of the excipients.
Omeprazole like other proton pump inhibitors (PPIs) should not be used concomitantly with nelfinavir .
Drug interactions:
Active substances with pH dependent absorption:
Nelfinavir, Atazanavir,Digoxin,Clopidogrel
Storage instructions:
Do not store above 25°C. Keep vials in the outer carton in order to protect from light.
Omeprazole Sodium For Injection Other Specifications:
| Product Code | Product Name | Specification |
| AMC13025-01 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML+5ML ,1'S+1'S/BOX |
| AMC13025-02 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML+10ML,1'S+1'S/BOX,5BOXES/MID BOX |
| AMC13025-03 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML+10ML,1'S+1'S/BOX |
| AMC13025-05 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML,1'S/BOX |
| AMC13025-06 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML,20'S/BOX |
| AMC13025-07 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/7ML,10'S/BOX |
| AMC13025-08 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/7ML+10ML,1'S+1'S/BOX |
| AMC13025-09 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/5ML,10VIALS/BOX |
| AMC13025-10 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML,50'S/BOX |
| AMC13025-11 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/7ML,50'S/BOX |
| AMC13025-12 | OMEPRAZOLE SODIUM FOR INJECTION | 40MG/10ML,5'S/BOX |
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