| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | For oral administration |
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Indications:
Treatment and maintenance therapy of active duodenal ulcer. Treatment of benign gastric ulcers. Treatment of reflux oesophagitis. Treatment of pathological hyper secretory conditions (Zoltinger-Elson Syndrome)
Contra-indications:
Cimetidine (HCI) is contraindicated in conditions like Hypersensitivity.
Adverse Effects:
Adverse reactions to cimetidine are generally infrequent and are usually reversible following a reduction of dosage or withdrawal of therapy. The commonest side-effects reported have been altered bowel habits, dizziness, tiredness, headache, and rashes, Reversible confusional states, especially in the elderly or in seriously ill patients such as those with renal failure, have occasionally occurred, Cimetidine has a weak anti-androgenic effect and gynaecomastia and impotence have also occasionally occurred in men receiving relatively high doses for conditions such as the Zollinger-Ellison syndrome, Other adverse effects which have been reported rarely are hypersensitivity reactions and fever, arthralgia and myalgia, blood disorders including agranulocytosis and thrombocytopenia, interstitial nephritis, hepatotoxicity and cardiovascular disorders including bradycardia and heart block.
Dosage:
Cimetidine should be administered preferably after meals or at bedtime. Doses should be adjusted to individual patients' needs & should continue as long as clinically indicated.
Precautions & Warning:
Before giving cimetidine to patients with gastric ulcers the possibility of malignancy should be considered since cimetidine may mask symptoms and delay diagnosis. It should be given in reduced dosage to patients with impaired renal function.
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