| Application: | Internal Medicine |
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| Usage Mode: | For oral administration |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Shape: | Tablet |
| Type: | Organic Chemicals |
| Samples: |
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| Customization: |
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Amlodipine Besylate Tablet
Indications:
Hypertension;Chronic stable angina pectoris;Vasospastic (Prinzmetal's) angina
Dosage and Administration
Usage: Tablet for oral administration.
Dosage:
1.Adults For both hypertension and angina the usual initial dose is 5 mg Istin once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response.
2.Elderly patients:Normal dosage regimens are recommended in the elderly
Patients with hepatic impairment: Amlodipine should be initiated at the lowest dose and titrated slowly in patients with severe hepatic impairment.
3.Paediatric population:The recommended antihypertensive oral dose in paediatric patients ages 6-17 years is 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks.
Precautions & Warning:
Patients with cardiac failure: should be treated with caution.
Patients with hepatic impairment:Slow dose titration and careful monitoring may be required in patients with severe hepatic impairment.
Elderly patients:In the elderly increase of the dosage should take place with care
Patients with renal impairment: Amlodipine is not dialysable.
Contraindications
1. hypersensitivity to dihydropyridine derivatives, amlodipine or to any of the excipients
2. severe hypotension.
3.shock (including cardiogenic shock).
4. obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis).
5. haemodynamically unstable heart failure after acute myocardial infarction.
Adverse Reactions
Summary of the safety profile
The most commonly reported adverse reactions during treatment are somnolence, dizziness, headache, palpitations, flushing, abdominal pain, nausea, ankle swelling, oedema and fatigue.
Storage instructions:
Do not store above 25°C
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