Indications: The mechanism of action of Methyldopa BP 250mg is probably due to its metabolite alphamethy-Inoradrenaline,which lowers arterial pressure by stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity,Methyldopa BP 250mg reduces both standing and supine blood pressure. Variations in diumai bfood pressure, symptomatic postural hypotension and exercise hypotension rarely occur.Careful adjustment of dosage avoids morning hypotension and does not affect the control of afternoon blood pressure. Methyfdopa BP 250mg has no direct effect on cardiac heart function, and does not reduce filtration fraction, renai blood flow or glomerular filtration rate. Methyldopa BP 250mg may be given with caiitfon to patients with renal dysfunction.Indications: Methyldopa 8P 250fTig tablets are indicated for the treatment of hypertension. Dosage: Adults; The innitial dose of Methyldopa BP 250iT»g tablets is usually 250mg two to three times daily for two days. The dose may be increased at intervals of not less than two days by an additional 250-50(}mg daily until satisfactory control is achieved.The maximum recommended daily dosage is 3g. Methyldopa BP 250mg is mainly excreted by the kidneys therefore patients with renal dysfunction may respond well to lower doses. The requirement of Methyldopa BP 250mg may be reduced by giving a thiazide diuretic concurrently: downward adjustment of dosage should likewise be made at intervals of less than 48 hours, When patients are on other hypotensive agents and it is desired to change them over to Methyfdopa BP 250mg, drug interactions must be carefully watched for When Methyldopa BP 250mg is given to patients on other antihypertensives the dose of these agents has to be adjusted to effect a smooth transition. Methyldopa BP 250mg may be used concurrently with Amiloride, and betablocking agents. Elderly: The initial dose Should not exceed 250mg daily. This should be increased slowly as required but not to exceed a maximum daily dose of 2g. Storage: Store in a cool, dry place. Protect from light. Validity: Three Years