ndications:
Treatment and maintenance therapy of active duodenal ulcer. Treatment
of benign gastric ulcers . Treatment of reflux oesophagitis. Treatment of pathological
hyper secretoryconditions(Zoltinger-Elllson Syndrome)
Contra-indications:
Cimetidine (HCI) is contraindicated in conditions like Hypersensitivity.
Adverse Effects:
Adverse reactions to cimetidine are generally infrequent and ars usually reversible following a reduction of dosage or wrthdrawal of therapy. The commonest side-effects reported have been altered bowel habit,dizziness,tiredness, headache and rashes,Reversible confusional states,especially in the elderly or in seriously ill patients such as those with renal failure, have occasionally occurred, Cimetidine has a weak anti-androgenic effect and gynaeconnastia and impotence have also occasionally occurred in men receiving relatively high doses for conditions such as the Zollinger-Ellison syndrome,Other adverse effects which have been reported rarely are hypersensitivity reactions and fever, arthralgia and myalgia, blood disorders including agranulocytosis and thrombocytopenia, interstitial nephritis, hepatotoxicity and cardiovascular disorders including bardycardia and heart block.
Dosage:
Cimetidine should be administered preferably after meals or at bed time.
Doses should be adjusted to individual patients needs & should continue as long as
clinically ndicated.
Precautions & Warning:
Before giving cimetidine to patients with gastric ulcers the possibility of
malignancy should be considered since cimetidine may mask symptoms and dely
diagnosis. It should be given in reduced dosage to patients with impaired renal function,
Intravenous injections of Cimetidine should be given slowly and intravenous infusion is
Storage instructions:
Store in a cool, dry & dark place. Keep away from children.
Validity: Three Years
Active duodenal ulcer:200/400 mg thrice daily for 4-5 weeks.
Maintenance therapy for duodenal ulc9r:400mg once or twice daily for 6 months
Active benign gastric ulcer:200/400 mg four times a day.
Reflux oesophagitis:400 mg t.Ld for 4-8 weeks.
Pathological hypersecretory conditions (such as Zollinger Ellison syndrome):
200/400 mg four times a day or as directed by the physician.
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