Pharmacological action:
Amoxicillin is a semi synthetic broad-spectrum penicillin drug. Its antibacterial spectrum and antibacterial activity are basically the same as ampicillin, but its acid resistance is stronger than ampicillin, and its bactericidal effect is stronger and faster than that of ampicillin, but it can not be used in the treatment of meningitis. The half-life is about 61.3 minutes. Amoxicillin was stable under acidic conditions, and the absorption rate of gastrointestinal tract was 90%, which was more rapid and complete than ampicillin. Amoxicillin has strong bactericidal effect and strong ability to penetrate cell wall. After oral administration, the lactam group in the drug molecule was hydrolyzed immediately to form peptide bond, which rapidly combined with transpeptidase to inactivate it. The only way for bacteria to synthesize glycopeptides by transpeptidase to construct cell wall was cut off. The bacterial cells rapidly became spherical bodies and broke and dissolved. Finally, the bacterial bodies were ruptured and died due to the loss of cell wall and the continuous infiltration of water. It has strong antibacterial and bactericidal effects on most pathogenic G + bacteria and G-bacteria (including cocci and bacilli). Among them, it has good antibacterial activity against Streptococcus pneumoniae, Streptococcus haemolyticus, aerobic Gram-positive cocci such as penicillinase producing Staphylococcus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic gram-negative bacteria, and Helicobacter pylori. Hemodialysis can remove some drugs, but peritoneal dialysis has no effect. Indication: Amoxicillin can be used to treat typhoid fever, other Salmonella infections and typhoid carriers. It can be used for the treatment of urinary tract infection caused by urinary tract infection. The indications are Streptococcus pneumoniae, Staphylococcus aureus without penicillinase, Streptococcus hemolyticus and Haemophilus influenzae without β - lactamase. Amoxicillin can also be used for leptospirosis. It can also be used for genitourinary infections caused by sensitive Escherichia coli, Proteus mirabilis and Enterococcus faecalis. The combination of clarithromycin and lansoprazole has good curative effect on Helicobacter pylori infection. Adverse reactions: The incidence of adverse reactions in clinical application of amoxicillin was about 5-6%, and the drug withdrawal was about 2%. The main adverse reactions were as follows: 1. Allergic reaction symptoms: drug fever, urticaria, rash and asthma may occur, especially in patients with infectious mononucleosis, and anaphylactic shock is rare. 2. Digestive system symptoms: diarrhea, nausea, vomiting and other symptoms are common, and gastrointestinal reactions such as pseudomembranous colitis are occasionally seen. 3. Blood system symptoms: occasionally eosinophilia, leucopenia, thrombocytopenia, anemia, etc. 4. Mucocutaneous reaction: occasional maculopapular, exudative erythema multiforme, Lyell syndrome, exfoliative dermatitis. 5. Disorder of liver and kidney function: a few patients had slight elevation of serum aminotransferase and acute interstitial nephritis. 6. Others: central nervous system symptoms such as excitement, anxiety, insomnia, dizziness and abnormal behavior. Long term use of this drug may lead to double infection caused by Candida or drug-resistant bacteria. 7. Convulsion and eosinophilia were observed in large intravenous injection.
Storage instructions:
Store below 25ºC. Protect from moisture. Keep out of reach of children.
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