TINIDAZOLE TABLETS 500 MG
COMPOSITION:
Each film-coated tablet contain: Tlnidazole 500 mg.
USES:
Actions:
The mode of action of tinidazole against anaerobic bacteria and protozoa involves penetration of the compound into fríe cell of the microorganism and subsequent damage of DNA strands or inhibition of their synthesis.
Tinidazole is active against both protozoa and obligate anaerobic bacteria. The activity against protozoa involves Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia.
Tinidazole is active against most anaerobic bacteria including Bacteroides fragilis, Bacteroides melaninogenicus, Bacteroides spp., Clostridium spp., Eubacterium spp., Fusobacterium spp., Gardnerella vaginalis, Peptococcus spp., Peptostreptococcus spp., And Veillonella spp.
Indications:
- ProphylaxisThe prevention of postoperative infections caused by anaerobic bacteria, especially those associated with colonic, gastrointestinal and gynecological surgery.
- Treatment of the following anaerobic infections.
Intraperitoneal infections: peritonitis, abscess; gynecologica I infections: endometritis, endomyometritis, tuboovarian abscess, bacterial septicaemia, post operative wound infections, skin and soft tissue infections, upper and lower respiratory tract infections: pneumonia, empyema, lung abscess.
- Nonspecific vaginitis
- Aoite ulcerative gingivitis
- Urogenital trichomoniasis in both male and female patients.
- Mixed trichomonal and candidal infections.
- Giardiasis
- Intestinal amoebiasis
- Amoebic involvement of ttie liver.
ADVERSE EFFECTS:
Reported side effects have generally been infrequent, mild and self-limiting.
Side effects from the gastrointestinal tract indude nausea, vomiting, anorexia, diarrhoea and metallic taste.
Hypersensitivity reactions, occasionally severe, may occur in rare cases in the form of skin rash, pmrítis, urticaria and angioneurotic oedema.
As with related compounds, tinidazole may produce transient leukopenia. Other rarely reported side-effects are headache, tiredness, furry tongue and dark urine.
INTERACTIONS:
Tinidazole and related compounds when taken together with alcoholic beverages have caused abdominal cramps, flushing and vomiting.
Closely related chemical compounds enhance the activity of warfarin. If Tinidazole is given to patients receiving warfarin or other anticoagulants, the dosage of the latter should be recalibrated.
STORAGE:
Store below 25°C and protect from light.
KEEP OUT OF REACH OF CHILDREN.