| Customization: | Available |
|---|---|
| Application: | Internal Medicine |
| Usage Mode: | Injection |
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Chloroquine phosphate injection is indicated for the treatment of falciparum malaria, vivax malaria, trivivax malaria and ovarian malaria patients who are sensitive to chloroquine. It can also be used to treat extraintestinal amoebiasis such as amoebic liver abscess. Wait for the patient to switch to oral medication when the condition improves.
character
This product is colorless or almost colorless clear liquid.
Indications
It is used to treat patients with chloroquine-sensitive falciparum malaria, vivax malaria, malaria ovale and malaria ovale that cannot be taken orally. It can also be used to treat patients with parenteral amoebiasis such as amebic liver abscess. Take oral medicine.
Specification
5ml: 322mg
| Specification | 5ml: 322mg |
Dosage
Cerebral malaria patients received an intravenous infusion of 18-24 mg/kg on the first day (calculated as 60 kg for those weighing more than 60 kg), 12 mg/kg on the second day, and 10 mg/kg on the third day. The concentration is that every 0.5g of chloroquine phosphate is added to 10% glucose solution or 500ml of 5% glucose sodium chloride injection, and the intravenous infusion rate is 12 to 20 drops per minute.
Adverse reactions
There may be photophobia, impaired color vision, decreased vision, and blindness in severe cases. It can also cause suppression of the sinus node, leading to arrhythmia, physical restraint, and in severe cases, A-Syndrome and even death.
Taboo
Patients with liver and kidney insufficiency and heart disease are forbidden.
Precautions
1. Use with caution in patients with severe erythema multiforme, porphyria, psoriasis and mental illness.
2. Chloroquine injection is not suitable for intramuscular injection, especially in children, it is easy to cause myocardial depression. Prohibited for intravenous injection.
3. Chloroquine can cause fetal hydrocephalus, limb deformities and deafness, so pregnant women are contraindicated.
Medication for pregnant and breastfeeding women
Pregnant and lactating women are prohibited.
Pediatric medicine
Dosage is the same as for adults, but intravenous administration should be used with caution.
Geriatric medication
Intravenous administration should be used with caution in elderly patients.
medicine interactions
1. This product is used together with phenylbutazone, which can easily cause allergic dermatitis.
2. Combined with chlorpromazine, it is easy to aggravate liver damage.
3. This product has a direct inhibitory effect on the neuromuscular junction, and streptomycin can aggravate this side effect.
4. After the application of this product in patients with digitalis, it is easy to cause heart block.
5. Combining this product with heparin or penicillamine can increase the chance of bleeding;
6. The combination of this product and primaquine can cure vivax malaria.
7. Combined with ammonium chloride, it can accelerate excretion and reduce blood concentration.
8. Concomitant use with monoamine oxidase inhibitors may increase toxicity.
9. Combination with fluroxyprednisolone can easily cause exfoliative erythroderma.
10. When used together with chloroquine congeners (aminophenoquine, hydroxychloroquine, etc.), it can increase the blood concentration of chloroquine.
drug overdose
Acute chloroquine poisoning is often fatal, and its lethal dose can be as low as 50 mg (substrate)/kg. Nausea, vomiting, and drowsiness appear rapidly, followed by slurred speech, agitation, visual impairment, dyspnea due to pulmonary edema, and even stop. , Arrhythmia, convulsions and coma. When these phenomena occur, the drug should be stopped immediately and symptomatic treatment should be carried out, especially to maintain cardiopulmonary function.
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