Indications:
Treatment of infections caused by penicillin-sensitive Gram-positive bacteria as well as H.Influenzas, E.Coli, P.Mirabilis, Salmonella and some Shigellosis species. Treatment of bronchitis, otitis media, bacterial pharyngitis, bacterial pneumonia, sinusitis, urinary tract infections.
Contra-indications:
Individuals with a history of an allergic reaction to the penicillins. It is also contraindicated in patients with a history of amoxicillin associated hepatic dysfunction of jaundice.
Adverse Effects:
Sensitivity reactions are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever or urticaria. The hypersensitivity reactions are Erythematous maculopapular rashes, urticaria, fever and joint pains. Anaphylactic shock may occur. Gastrointestinal :diarrhoea, nausea, vomiting, heartburn, pseudomembranous colitis Liver: A moderate rise in serum glutamic oxalacetic transaminase has been noted, but the significance of this finding is unknown. Haemic and Lymphatic Systems: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia and granulocytopenia have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. Central Nervous System: Reversible hyperactivity, agitation, anxiety, confusion, behavioural changes and/or dizziness.
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