Artemether and Lumefantrine Suspension for Effective Malaria Treatment

• Customization: Available
• Application: Internal Medicine
• Usage Mode: For oral administration
• Model NO.: AMC16008-01
• State: Liquid
• Shape: Oral Liquid
• Type: Organic Chemicals
• Pharmaceutical Technology: Chemical Synthesis
• Packing: 15mg+90mg/5ml,60ml, 200boxes/CTN
• CTN Size: 49*49*26.5cm
• OEM/ODM: Support
• Transport: Shipping
• Transport Package: 1 Bottle/Box
• Specification: 15mg+90mg/5ml, 60ml
• Trademark: Medipharm or OEM
• Origin: China
• HS Code: 3004909099
• Production Capacity: 100000ctns/Month

Product Description

Product Description
 

ACTIVE INGREDIENTS: Artemether and Lumefantrine
COMPOSITION:
Artemether + lumefantrine suspension (Artemether 180mg+Lumefantrine 1080mg in 100ml bottle).
ARTEMETHER + LUMEFANTRINE SUSPENSION:
Artemether is the most active derivative of the Artemisinin, a new class of antimalarial drugs derived from Artemisinin. The latter compound is extracted from the plant Artemisia Annua and Artemether is prepared semi-synthetically. Lumefantrine is a synthetic aryl amino alcohol similar to mefloquine and halofantrine.
PHARMACOLOGICAL PROPERTIES:
Pharmacodynamics: Both components of artemether + lumefantrine suspension have their own action site in the malarial parasite. The presence of the endoperoxide bridge in Artemether (generating singlet oxygen and free radicals: those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity. Morphological changes of the parasitic membranes induced by Artemether have been described, being the result of free-radical action.
Lumefantrine interferes more in the polymerization processes. Other in vitro test suggest that both cause a marked diminution of nucleic acid synthesis. Inhibition of protein synthesis as the basic mechanism of action is suggested in studies which showed morphological changes in ribosomes as well in the endoplasmic reticulum. Although Artemether acts essentially as a blood schizonticide, artemether + lumefantrine suspension did clear gametocytes in comparative clinical trials.
INDICATIONS:
ARTEMETHER + LUMEFANTRINE SUSPENSION is indicated for the treatment of malaria in children caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. Falciparum.
PHARMACEUTICAL PRECAUTIONS AND CONTRA-INDICATIONS:
Artemether + lumefantrine suspension is contraindicated in individuals hypersensitive to Artemether and Lumefantrine. Therefore, there are no strict contra-indications for the use of Artemether in children. Nevertheless, no correlation has been found between QT interval prolongation and plasma concentration of lumefantrine caution is advised to patients who are taking drugs that are known to prolong the QT interval, such as certain antibiotics (macrolides, fluoroquinolones, imidazole) or who are predisposed to cardiac arrhythmias. It is advisable not to use drugs pregnancy but in view of the high risk of malaria during pregnancy for mother and foetus, the responsible physician may consider it essential, as in the case of cerebral malaria, to treat a pregnant woman, Artemisinin derivatives like Artemether are the fastest acting schizonticides and rapid clearance of parasites is essential. Since artemether + lumefantrine suspension has been designed for its use in children it is unlikely that this problem arises. Artemether + lumefantrine suspension should not be taken during breast-feeding. Due to the long elimination half-life of lumefantrine, it is recommended that breast-feeding should not start until at least one week after stopping an Artemether/ Lumefantrine combination treatment.
DRUG INTERACTION:
Specific negative drug interactions were not seen. Artemether potentialize the antimalarial activity of other antimalarials. As grapefruit juice retards the metabolism of some antimalarials, it would be better not to drink grapefruit juice while taking artemether + lumefantrine suspension.
DOSAGE AND ADMINISTRATION:

Body weight	Number of Milliliters
	1"Day	2" Day	3" Day
5 Kgs	7 ml	7 ml	7 ml
7.5 Kgs	10 ml	10 ml	10 ml
10 Kgs	14 ml	14 ml	14 ml
15 Kgs	20 ml	20 ml	20 ml

PHARMACEUTICAL PRECAUTIONS:
Artemether + lumefantrine suspension bottles should be stored below 25ºC. in a closed bottle artemether + lumefantrine suspension powders are stable. Once the suspension has been made up, it is stable for a minimum of 14 days. Longer conservation is not recommended.
SHELF LIFE: 3 Years.
DISPENSING CATEGORY: Prescription medicine.
PRESENTATION: Each cardboard box contains 1 bottle.

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