| Application: | Internal Medicine |
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| Usage Mode: | For oral administration |
| Suitable for: | Elderly, Children, Adult |
| State: | Solid |
| Shape: | Tablet |
| Type: | Organic Chemicals |
| Samples: |
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| Customization: |
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Indications
Prophylaxis and treatment of iron deficiency states.
For prophylaxis during pregnancy, a combination of iron and folic acid is usually recommended.
Dosage and Administration
Usage: Oral
Adults and the elderly:
Iron deficiency anaemia - 1 tablet two to three times a day;
Prophylaxis - 1 tablet once or twice a day.
Paediatric population:
Not recommended.
Precautions & Warning:
1. Some post-gastrectomy patients show poor absorption of iron. Care is required when treating patients with iron deficiency anaemia who have treated or controlled peptic ulceration.
2. Because anaemia due to combined iron and Vitamin B12 or folate deficiencies may be microcytic in type, patients with microcytic anaemia resistant to treatment with iron alone should be screened for Vitamin B12 or folate deficiency.
3. Paediatric population: ferrous fumarate should be kept out of the reach of children.Keep out of the reach and sight of children, as overdose may be fatal.
4. Important Warning: Contains Iron.
Keep out of the reach and sight of children, as overdose may be fatal.
Contraindications:
1.Hypersensitivity to the active substance or to any of the excipients.
2. Paroxysmal nocturnal haemoglobinuria. Haemosiderosis, haemochromatosis. Active peptic ulcer. Repeated blood transfusions. Regional enteritis and ulcerative colitis. Must not be used in anaemias other than those due to iron deficiency.
Adverse Reactions:
The following adverse reactions are classified by system organ class and ranked under heading of frequency using the following convention:
Common (≥1/100 to <1/10)
Gastrointestinal disorders:
The commonest side effects relate to gastrointestinal irritation (nausea, epigastric pain, constipation or diarrhoea). In the event of these ADRs, it may be helpful to reduce the dose or switch to an alternative iron salt. Darkening of stools may also occur.
Drug interactions:
Iron reduces the absorption of penicillamine, bisphosphonates, ciprofloxacin, entacapone, levodopa, levofloxacin, levothyroxine (thyroxine) (give at least 2 hours apart), moxifloxacin, mycophenolate, norfloxacin, ofloxacin, zinc. Absorption of both iron and antibiotic may be reduced if Ferrous fumarate tablets is given with tetracycline.
Absorption of oral iron is reduced by calcium salts, Magnesium salts (as magnesium trisilicate), Trientine.
Chloramphenicol delays plasma iron clearance, incorporation of iron into red blood cells and interferes with erythropoiesis. Some inhibition of iron absorption may occur if it is taken with cholestyramine, tea, eggs or milk.
Avoid concomitant use of iron with dimercaprol.
Oral iron antagonises hypotensive effect of methyldopa.
Storage instructions:
Do not store above 30 ºC, and store in the original packaging.
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